Publikationen

Mechanism and regulation of secondary immunoglobulin diversification. Externer Link Bello A, Hirth G, Voigt S, Tepper S, Jungnickel B. Cell Cycle. 2023 Nov 1:1-18

Soluble Enolase 1 of Candida albicans and Aspergillus fumigatus Stimulates Human and Mouse B Cells and Monocytes. Externer Link Langenhorst D, Fürst AL, Alberter K, Vilhena C, Dasari P, Daud M, Heilig L, Luther CH, Dittrich M, Reiher N, Wich M, Elmowafy M, Jacobsen ID, Jungnickel B, Zipfel PF, Beyersdorf N. J Immunol. 2023 Sep 1;211(5):804-815

Cell Cycle-Mediated Regulation of Secondary Ig Diversification. Externer Link Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B. J Immunol. 2023 May 15;210(10):1508-1518

The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Externer LinkLichtheimia corymbifera, a causative agent of invasive mucormycosis. Externer Link Montaño DE, Hartung S, Wich M, Ali R, Jungnickel B, von Lilienfeld-Toal M, Voigt K. Front Immunol. 2022 Oct 13;13:882921

3D Bioprinting of Prevascularized Full-Thickness Gelatin-Alginate Structures with Embedded Co-Cultures. Externer Link Böttcher B, Pflieger A, Schumacher J, Jungnickel B, Feller KH. Bioengineering (Basel). 2022 May 31;9(6):242

Systemic Candidiasis in Mice: New Insights From an Old Model. Externer Link Jungnickel B, Jacobsen ID. Front Fungal Biol. 2022 Jun 23;3:940884

Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth. Externer Link Halder LD, Babych S, Palme DI, Mansouri-Ghahnavieh E, Ivanov L, Ashonibare V, Langenhorst D, Prusty B, Rambach G, Wich M, Trinks N, Blango MG, Kornitzer D, Terpitz U, Speth C, Jungnickel B, Beyersdorf N, Zipfel PF, Brakhage AA, Skerka C. mBio. 2021 Feb 22;13(1):e0356321

Functionality of the human antibody response to Externer LinkCandida albicans. Externer Link Wich M, Greim S, Ferreira-Gomes M, Krüger T, Kniemeyer O, Brakhage AA, Jacobsen ID, Hube B, Jungnickel B. Virulence. 2021 Dec;12(1):3137-3148

B Cell Recognition of Externer LinkCandida albicans Hyphae Externer Linkvia TLR 2 Promotes IgG1 and IL-6 Secretion for TExterner Link_H17 Differentiation. Externer Link Ferreira-Gomes M, Wich M, Böde S, Hube B, Jacobsen ID, Jungnickel B. Front Immunol. 2021 Nov 8;12:698849

Context-dependent regulation of immunoglobulin mutagenesis by p53. Externer Link Böttcher K, Braunschmidt K, Hirth G, Schärich K, Klassert TE, Stock M, Sorgatz J, Fischer-Burkart S, Ullrich S, Frankenberger S, Kritsch D, Kosan C, Küppers R, Strobl LJ, Slevogt H, Zimber-Strobl U, Jungnickel B. Mol Immunol. 2021 Oct;138:128-136.

Impact of Chk1 dosage on somatic hypermutation in vivo. Externer Link Bello A, Jungnickel B. Immunol Cell Biol. 2021 Sep;99(8):879-893.

ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation. Externer Link Scheffler L, Feicht S, Babushku T, Kuhn LB, Ehrenberg S, Frankenberger S, Lehmann FM, Hobeika E, Jungnickel B, Baccarini M, Bornkamm GW, Strobl LJ, Zimber-Strobl U. Sci Signal. 2021 May 11;14(682):eabc1648.

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Externer Link Halder LD, Jo EAH, Hasan MZ, Ferreira-Gomes M, Krüger T, Westermann M, Palme DI, Rambach G, Beyersdorf N, Speth C, Jacobsen ID, Kniemeyer O, Jungnickel B, Zipfel PF, Skerka C. Nat Commun. 2020 May 11;11(1):2331.

Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination. Externer Link Hirth G, Svensson CM, Böttcher K, Ullrich S, Figge MT, Jungnickel B. J Immunol. 2019 Sep 15;203(6):1493-1501

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. Externer Link Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C. Nat Commun. 2019 Jul 4;10(1):2961

The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling. Externer Link Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C. J Biol Chem. 2019 Aug 2;294(31):11741-11750

Restriction of AID activity and somatic hypermutation by PARP-1. Externer Link Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H, Jungnickel B. Nucleic Acids Res. 2019 Aug 22;47(14):7418-7429.

PARP activation promotes nuclear AID accumulation in lymphoma cells. Externer Link Tepper S, Jeschke J, Böttcher K, Schmidt A, Davari K, Müller P, Kremmer E, Hemmerich P, Pfeil I, Jungnickel B. Oncotarget. 2016 Mar 15;7(11):13197-208

Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Externer Link Davari K, Frankenberger S, Schmidt A, Tomi NS, Jungnickel B. Cell Cycle. 2014;13(23):3659-69

Analysis of SHPRH functions in DNA repair and immunoglobulin diversification. Externer Link Tomi NS, Davari K, Grotzky D, Loos F, Böttcher K, Frankenberger S, Jungnickel B. DNA Repair (Amst). 2014 Dec;24:63-72

Checkpoint kinase 1 negatively regulates somatic hypermutation. Externer Link Frankenberger S, Davari K, Fischer-Burkart S, Böttcher K, Tomi NS, Zimber-Strobl U, Jungnickel B. Nucleic Acids Res. 2014 Apr;42(6):3666-74.

c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma. Externer Link Scheller H, Tobollik S, Kutzera A, Eder M, Unterlehberg J, Pfeil I, Jungnickel B. Oncogene. 2010 Feb 11;29(6):888-97

Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells. Externer Link Ertongur I, Tomi NS, Kutzera A, Fischer-Burkart S, Jungnickel B. Nucleic Acids Res. 2010 Aug;38(14):4701-7

Willenbrock K, Renne C, Rottenkolber M, Klapper W, Dreyling M, Engelhard M, Kuppers R, Hansmann ML, Jungnickel B. The expression of activation induced cytidine deaminase in follicular lymphoma is independent of prognosis and stage. Histopathology. 2009;54(4):509-12. doi: 10.1111/j.1365-2559.2009.03241.x. PubMed PMID: 19309412.

Mierau M, Drexler GA, Kutzera A, Braunschmidt K, Ellwart J, Eckardt-Schupp F, Fritz E, Bachl J, Jungnickel B. Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription. Nucleic Acids Res. 2008;36(17):5591-601. doi: 10.1093/nar/gkn542. PubMed PMID: 18757891; PubMed Central PMCID: PMCPMC2553578.

Engels K, Jungnickel B, Tobollik S, Hansmann ML, Kriener S, Willenbrock K. Expression of activation-induced cytidine deaminase in malignant lymphomas infiltrating the bone marrow. Appl Immunohistochem Mol Morphol. 2008;16(6):521-9. doi: 10.1097/PAI.0b013e3181758ce5. PubMed PMID: 18776814.

Tobollik S, Meyer L, Buettner M, Klemmer S, Kempkes B, Kremmer E, Niedobitek G, Jungnickel B. Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth. Blood. 2006;108(12):3859-64. doi: 10.1182/blood-2006-05-021303. PubMed PMID: 16882707.

Jungnickel B. False moves for survival: error-prone DNA repair in adaptive immunity. Cell Cycle. 2006;5(24):2856-61. doi: 10.4161/cc.5.24.3564. PubMed PMID: 17172871.

Bachl J, Ertongur I, Jungnickel B. Involvement of Rad18 in somatic hypermutation. Proc Natl Acad Sci U S A. 2006;103(32):12081-6. doi: 10.1073/pnas.0605146103. PubMed PMID: 16873544; PubMed Central PMCID: PMCPMC1567700.

Willenbrock K, Jungnickel B, Hansmann ML, Kuppers R. Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase. Eur J Immunol. 2005;35(10):3002-7. doi: 10.1002/eji.200535134. PubMed PMID: 16180254.

Montesinos-Rongen M, Schmitz R, Courts C, Stenzel W, Bechtel D, Niedobitek G, Blumcke I, Reifenberger G, von Deimling A, Jungnickel B, Wiestler OD, Kuppers R, Deckert M. Absence of immunoglobulin class switch in primary lymphomas of the central nervous system. Am J Pathol. 2005;166(6):1773-9. doi: 10.1016/S0002-9440(10)62487-X. PubMed PMID: 15920162; PubMed Central PMCID: PMCPMC1602401.

Mancao C, Altmann M, Jungnickel B, Hammerschmidt W. Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus. Blood. 2005;106(13):4339-44. doi: 10.1182/blood-2005-06-2341. PubMed PMID: 16076866; PubMed Central PMCID: PMCPMC1895254.

Greiner A, Tobollik S, Buettner M, Jungnickel B, Herrmann K, Kremmer E, Niedobitek G. Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma. J Pathol. 2005;205(5):541-7. doi: 10.1002/path.1746. PubMed PMID: 15732141.

Schwering I, Brauninger A, Klein U, Jungnickel B, Tinguely M, Diehl V, Hansmann ML, Dalla-Favera R, Rajewsky K, Kuppers R. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood. 2003;101(4):1505-12. doi: 10.1182/blood-2002-03-0839. PubMed PMID: 12393731.