Bioinstrumentation center

Cell Biology

Professorship for Cell Biology
Bioinstrumentation center
Image: Winckler

Prof. Berit Jungnickel and her team are investigating the biology of B-lymphocytes, cells of the adaptive immune system. Two priorities exist: 

A) Mechanisms and regulation of somatic hypermutation, which changes the genes of our antibodies during acute infections, resulting in the production of effective antibodies. However, this pathway changes to a lower extent non-antibody genes, too, and this could lead to genetic instability of B cells and the development of lymphomas. We examine basic mechanisms of this process and regulatory pathways.

B) B cell reaction against Candida albicans, a fungus that lives as a benign commensal on human mucosal membranes. Upon immune suppression, however, Candida albicans can change into a pathogen and killer. We investigate how B cells react against Candida infections and which defence role antibodies may play.

Professorship of Cell Biology
Center for Molecular Biomedicine (CMB), Room Bioinstrumente-Zentrum (BIZ)
Winzerlaer Straße 2
07745 Jena
Postal address:
Hans-Knöll-Straße 2
07745
Jena
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