Publications of the department since 2008. For older articles of Prof. Dr. S. H. Heinemann see PubMed.
Image: Jan-Peter Kasper (University of Jena)
  • 2024

    Rühl, P., A.G. Nair, N. Gawande, S.N.C.W. Dehiwalage, L. Münster, R. Schönherr, S.H. Heinemann
    An ultrasensitive fluorescent voltage indicator uncovers the electrical activity of non-excitable cells.
    Advanced Science 2307930. doi: 10.1002/advs.202307938. PMID: 38526185

    Arlt, F.A., R. Miske, M.-L. Machule, P. Broegger Christensen, S. Mindorf, B. Teegen, K. Borowski, M. Buthut, R. Rößling, E. Sanchez-Sendin. S. van Hoof. C. Cordero-Gómez, I. Bünger, H. Radbruch, A. Kraft, I. Ayzenberg. J. Klausewitz, N. Hansen. C. Timäus, P. Körtvelyessy, T. Postert, K. Baur-Seack, C. Rost, R. Brunkhorst, K. Doppler, N. Haigis, G. Hamann, A. Kunze, A. Stützer, M. Maschke, N. Melzer, F. Rosenow, K. Siebenbrodt, C. Stenør, M. Dichgans, M.K. Georgakis, R. Fang, G.C. Petzold, M. Görtler, I. Zerr, S. Wunderlich, I. Mihaljevic, P. Turko, M. Schmidt Ettrup, E. Buchholz, H. Foverskov Rasmussen, M. Nasouti, I. Talucci, H.M. Maric, S.H. Heinemann, M. Endres, DEMAS study group, L. Komorowski, H. Prüss
    KCNA2 Ig2 autoimmunity in neuropsychiatric diseases.
    Brain, Behavior, and Immunity 117, 399-411. doi: 10.1016/j.bbi/2024.01.220. PMID: 38309639

  • 2023

    Hussein, R.A., M. Ahmed,  S.H. Heinemann
    Selenomethionine mis-incorporation and redox-dependent voltage-gated sodium channel gain of function.
    Journal of Neurochemistry 167(2), 262-276. doi: 10.1111/jnc15957.PMID: 37679952.

    Loose, S., A. Lischka, S. Kuehs, C. Nau, S.H. Heinemann, I. Kurth, E. Leipold
    Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels.
    Pflügers Archiv 175(11), 1343-1355. doi: 10.1007/s00424-023-02856-2. PMID: 37695396

  • 2022

    Hussein, R.A., M. Ahmed, N. Kuldyushev, R. Schönherr, S.H. Heinemann
    Selenomethionine incorporation in proteins of individual mammalian cells determined with a genetically encoded fluorescent sensor.
    Free Radical Biology and Medicine 192, 191-199. doi: 10.1016/j.freeradbiomed.2022.09.019. PMID: 36152916

    Gessner, G., M. Jamili, P. Tomcyzk, D. Menche, R. Schönherr, T. Hoshi, S.H. Heinemann
    Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels.
    Biological Chemistry 403(11-12), 1067-1081. doi: 10.1515/hsz-2022-0194. PMID: 36038266

    Sahoo, N., I. Coburger, K. Yang, A. Bernert, S.M. Swain, G. Gessner, R. Kappl, T. Kühl, D. Imhof, T. Hoshi, R. Schönherr, S.H. Heinemann
    Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.
    Scientific Reports 12, 14645. doi: 10.1038/s41598-022-18975-2. PMID: 36030326

    Kuldyushev, N., R. Schönherr, I. Coburger, M. Ahmed, R.A. Hussein, E. Wiesel, A. Godbole, T. Pfirrmann, T. Hoshi, S.H. Heinemann
    A GFP-based fluorescent sensor for methionine oxidation.
    Talanta 243, 123332. link. PMID: 35276500

    Pirschel, W., A.N. Mestekemper, B. Wissuwa, N. Krieg, S. Kröller, C. Daniel, F. Gunzer, E. Tolosano, M. Bauer, K. Amann, S.H. Heinemann, S.M. Coldewey
    Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice.
    Kidney Int S0085-2538(22)00016-3. doi: 10.1016/j.kint.2021.12.024. PMID: 35031328

  • 2021

    Rühl, P., J.M. Langner, J. Reidel, R. Schönherr, T. Hoshi, S.H. Heinemann
    Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators.
    Communications Biology 4(1), 1164. PMID: 34620975

    Drees, C., P. Rühl, J. Czerny, G. Chandra, J. Bajorath, M. Haase, S.H. Heinemann, J. Piehler
    Diffraction-unlimited photomanipulation at the plasma membrane via specifically targeted upconversion nanoparticles.
    Nano Letters 21, 8025-8034 link. PMID: 34519216

    Lu, Y., W. Zhang, B. Zhang, S.H. Heinemann, T. Hoshi, S. Hou, G. Zhang
    Bilirubin oxidation end products (BOXes) induce neuronal oxidative stress involving the Nrf2 pathway.
    Oxidative Medicine and Cellular Longevity Article ID 8869908. DOI: 10.1155/2021/8869908. PMID: 34373769

    Rühl, P., D. Wang., F. Garwe, R. Müller, M. Haase, R. Heintzmann, K.W. Krämer, W. Paa, S.H. Heinemann, H. Stafast
    Notes on thermometric artefacts by Er3+ luminescence band interference.
    Journal of Luminescence 232, 117860

    Tian, Y., S.H. Heinemann, T. Hoshi
    Regulation of large-conductance Ca2+- and voltage-gated Slo1 K+ channels by electrostatic interactions with auxiliary β subunits.
    BioRxiv 2021.02.22.432338. DOI: 10.1101/2021.02.22.432338.

    Sussmilch, F.C., J. Böhm, G. Gessner, T. Maierhofer, T.D. Müller, S.H. Heinemann, D. Becker, R. Hedrich
    The liverwort Marchantia polymorpha operates a depolarization-activated Slowpoke (SLO) potassium channel that recognizes pH changes in the environment.
    BioRxiv 2021.06.01.446568. DOI: 10.1101/2021.06.01.446568

  • 2020

    Gessner G., P. Rühl, M. Westerhausen, T. Hoshi, S.H. Heinemann
    Fe2+-mediated activation of BKCa channels by rapid photolysis of CORM-S1 releasing CO and Fe2+.
    ACS Chemical Biology 15(8) 2098-2106. PMID: 32667185

    Böhme, I., R. Schönherr, R. Eberle, A.K. Bosserhoff 
    Membrane transporters and channels in melanoma.
    Reviews of Physiology, Biochemistry and Pharmacology, Springer, Berlin, Heidelberg,
    DOI: 10.1007/112_2020_17. PMID: 32737752

    Coburger, I., K. Yang, A. Bernert, E. Wiesel, S.M. Swain, N. Sahoo, R. Schönherr, T. Hoshi, S.H. Heinemann
    Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels.
    Pflügers Archiv 472 551-560. PMID: 32388729

  • 2019

    Wissbrock, A., N.B. Goradia, A. Kumar, A.A. Paul George, T. Kühl, P. Bellstedt, R. Ramachandran, P. Hoffmann, K. Galler, J. Popp, U. Neugebauer, K. Hampel, B. Zimmermann, S. Adam, M. Wiendl, G. Kronke, I. Hamza, S.H. Heinemann, S. Frey, A. Hueber, O. Ohlenschläger, D. Imhof
    Structural insights into heme binding to IL-36α proinflammatory cytokine.
    Scientific Reports 9 16893. PMID: 31729440

    Englert, F.A., R.A. Seidel, K. Galler, Z. Gouveia, M.P. Soares, U. Neugebauer, M.G. Clemens, C. Sponholz, S.H. Heinemann, G. Pohnert, M. Bauer, S. Weis
    Labile heme impairs hepatic microcirculation and promotes hepatic injury.
    Archives of Biochemistry and Biophysics 672 108075. PMID: 31412260

    Ojha, N.K., J. Jin, J.C. Arifin, P. Rühl, S.H. Heinemann
    Membrane potential manipulation with visible flash lamp illumination of targeted microbeads.
    Biochemical and Biophysical Research Communications 517(2) 297-302. PMID: 31353087

    Paul George, A.A., P. Heimer, E. Leipold, T. Schmitz, D. Kaufmann, D. Tietze, S.H. Heinemann, D. Imhof
    Effect of conformational diversity on the bioactivity of µ-conotoxin PIIIA disulfide isomers.
    Marine Drugs 17 390. PMID: 31269696

    Fischer, D., G. Gessner, T.P. Fill, R. Barnett, K. Tron, K. Dornblut, F. Kloss, P. Stallforth, B. Hube, S.H. Heinemann, C. Hertweck, K. Scherlach, S. Brunke
    Disruption of membrane integrity by the bacteria-derived antifungal jagaricin.
    Antimicrobial Agents and Chemotherapy 63(9). PMID: 31235622

    Prüß, H., G. Gessner, S.H. Heinemann, F. Rüschendorf, A.-K. Ruppert, H. Schulz, T. Sander, W. Rimpau
    Linkage evidence for a two-locus inheritance of LQT-associated seizures in a multigenerational LQT family with a novel KCNQ1 loss-of-function mutation.
    Frontiers in Neurology 10 648. PMID: 31293497

    Andrushchenko, V., W. Pohle
    Influence of the hydrophobic domain on the self-assembly and hydrogen bonding of hydroxy-amphiphiles.
    Physical Chemistry Chemical Physics 21 11242-11258. PMID: 31099371

    Tian, Y., S.H. Heinemann, T. Hoshi
    Large-conductance Ca2+- and voltage-gated K+ channels form and break interactions with membrane lipids during each gating cycle.
    Proceedings of the National Academy of Sciences USA 116(17) 8591-8596. PMID: 30967508

    Gessner, G., Runge, S., M. Koenen, S.H. Heinemann, M. Koenen, J. Haas, B. Meder, D. Thomas, H.A. Katurs, P.A. Schweizer
    ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.
    Biochemical and Biophysical Research Communications 512(4) 845-851. PMID: 30929919

    Peigneur, S., O. Cheneval, M. Maiti, E. Leipold, S.H. Heinemann, E. Lescrinier, P. Herdewijn, M.E. DeLima, D.J. Craik, C.I. Schroeder, J. Tytgat
    Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.
    The FASEB Journal 33(3) 3693-3703. PMID: 30509130

    Yang, K., I. Coburger, J. Langner, N. Peter, T. Hoshi, R. Schönherr, S.H. Heinemann
    Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.
    Pflügers Archiv – European Journal of Physiology 471 557-571. PMID: 30415410

  • 2018

    Jentho, E., T. Lajqi, K. Yang, R. Winkler, M. Stojiljkovic, R. Wetzker, M. Bauer
    Pathogen-induced hormetic responses
    in: "The Science of Hormesis in Health and Longevity" (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press p. 326

    Wissuwa, B., S.H. Heinemann, M. Bauer, S.M. Coldewey
    Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition.
    Life Sciences 203 112-120. PMID: 29684444

    Martin, C., C. Stoffer, M. Mohammadi, J. Hugo, E. Leipold, B. Oehler, H.L. Rittner, R. Blum
    NaV1.9 potentiates oxidized phospholipid-induced TRP responses only under inflammatory conditions.
    Frontiers in Molecular Neuroscience 11 7. PMID: 29410612

  • 2017

    Mede, R., P. Hoffmann, M. Klein, H. Görls, M. Schmitt, U. Neugebauer, G. Gessner, S.H. Heinemann, J. Popp, M. Westerhausen
    A water-soluble Mn(CO)3-based and non-toxic photoCORM for administration of carbon monoxide inside of cells.
    ZAAC - Journal of Inorganic and General Chemistry 643 2057-2062

    Gessner, G., N. Sahoo, S.M. Swain, G. Hirth, R. Schönherr, R. Mede, M. Westerhausen, H.H. Brewitz, P. Heimer, D. Imhof, T. Hoshi, S.H.Heinemann
    CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).
    European Journal of Pharmacology 815 33-41. PMID: 28987271

    King, M.K., E. Leipold, J.M. Goehringer, I. Kurth, T.D. Challman
    Pain insensitivity: distal S6-segment mutations in NaV1.9 emerge as critical hotspot.
    Neurogenetics 18 179-181. PMID: 28289907

    Lolignier, S., D. Gkika, D. Andersson, E. Leipold, I. Vetter, F. Viana, J. Noël, J. Busserolles
    New insight in cold pain: role of ion channels, modulation, and clinical perspectives.
    Journal of Neuroscience 36 11435-11439. PMID: 27911746

    Seidel, R.A., T. Claudel, F.A. Schleser, N.K. Ojha, M. Westerhausen, S. Nietzsche, C. Sponholz, F. Cuperus, S.M. Coldewey, S.H. Heinemann, G. Pohnert, M. Trauner, M. Bauer
    Impact of higher-order heme degradation products on hepatic function and hemodynamics.
    Journal of Hepatology 67 272-281. PMID: 28412296

    Ojha, N.K., E. Leipold, R. Schönherr, T. Hoshi, S.H. Heinemann
    Non-photonic sensing of membrane-delimited reactive species with a Na+ channel protein containing selenocysteine.
    Scientific Reports 7 46003. PMID: 28378799

    Mede, R., J. Traber, M. Klein, H. Görls, G. Gessner, P. Hoffmann, M. Schmitt, J. Popp, S.H. Heinemann, U. Neugebauer, M. Westerhausen
    Synthesis and solution stability of water-soluble κ2NO-bis(3,4-dimethylpyrazolyl)ethanol manganese(I) tricabonyl bromide (CORM-ONN1).
    Dalton Transactions 46 1684-1693. PMID: 28102423

    Leipold, E., F. Ullrich, M. Thiele, A.A. Tietze, H. Terlau, D. Imhof, S.H. HeinemannSubtype-specific block of voltage-gated K+ channels by µ-conopeptides.
    Biochemical and Biophysical Research Communications 482 1135-1140. PMID: 27916464

    Jadhav, K.B., C. Stein, O. Makarewicz, R.J. Lichtenecker, G. Pradel, H. Sack, S.H. Heinemann, H.-D. Arndt
    Bioactivity of topologically confined gramicidin A dimers.
    Bioorganic & Medicinal Chemistry 25 261-268. PMID: 27865644

  • 2016

    Tian, Y., M. Aursnes, T.V. Hansen, J. Galpin, L. Leisle, C. Ahern, R. Xu, S.H. Heinemann, T. Hoshi
    Atomic determinants of BK channel activation by polyunsaturated fatty acids.
    Proceedings of the National Academy of Sciences USA 113(48) 13905-13910  PMID: 27849612

    Marques-Carvalho, M.J., J. Oppermann, E. Munoz, A.S. Fernandes, G. Gabant, M. Cadene, S.H. Heinemann, R. Schönherr, J.H. Morais-Cabral
    Molecular insights into the mechanism of calmodulin inhibition of the EAG1 potassium channel.
    Structure 24 1-13 PMID: 27618660

    Tietze, D., E. Leipold, P. Heimer, M. Böhm, W. Winschel, D. Imhof, S.H. Heinemann, A.A. Tietze
    Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels.
    Biochimica et Biophysica Acta General Subjects 1860 2053-2063 PMID: 27316322

    Zhu, Q., R. El-Mergawy, Y. Zhou, C. Chen, S.H. Heinemann, R. Schönherr, D. Robaa, W. Sippl, G.K.E. Scriba
    Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.
    Electrophoresis 37 2083-2090 PMID: 27145186

    Hoshi, T., S.H. HeinemannModulation of BK channels by small endogenous molecules and pharmaceutical channel openers.
    International Review of Neurobiology 128 193-237 PMID: 27238265

    Han, B., M. Zhang, K. He, C. Cai, Y. Tang, L. Yang, S.H. Heinemann, T. Hoshi, S. Hou
    Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.
    Scientific Reports 6 23417 PMID: 27005320

    Mede, R., M. Klein, R.A. Claus, S. Krieck, S. Quickert, H. Görls, U. Neugebauer, M. Schmitt, G. Gessner, S.H. Heinemann, J. Popp, M. Bauer, M. Westerhausen
    CORM-EDE1 A highly water-soluble and non-toxic manganese-based photoCORM with a biogenic ligand sphere.
    Inorganic Chemistry 55 104-113 PMID: 26672620

    Schink, M., E. Leipold, J. Schirmeyer, R. Schönherr, T. Hoshi, S.H. Heinemann
    Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons.
    Pflügers Archiv, European Journal of Physiology 468 99-110 PMID: 26383867

  • 2015

    Leipold, E., A. Hanson-Kahn, M. Frick, P. Gong, J.A. Bernstein, M. Voigt, I. Katona, R.O. Goral, J. Altmüller, P. Nürnberg, J. Weiss, C.A. Hübner, S.H. Heinemann, I. Kurth
    Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.
    Nature Communications 6 10049 PMID: 26645915

    Swain, S.M., N. Sahoo, S. Dennhardt, R. Schönherr, S.H. Heinemann
    Ca2+/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K+ channels.
    Scientific Reports 5 15509 doi: 10.1038/srep15509 PMID: 26487174

    Bode, H.B., A.O. Brachmann, K.B. Jadhav, L. Seyfarth, C. Dauth, S.W. Fuchs, M. Kaiser, N.R. Waterfield, H. Sack, S.H. Heinemann, H.D. Arndt
    Structure elucidation and activity of kolossin A, the D-/L-pentadecapeptide product of a giant nonribosomal peptide synthetase.
    Angewandte Chemie International Edition 54(35) 10352-10355 PMID: 26118790

    Goral, R.O., E. Leipold, E. Nematian-Ardestani, S.H. Heinemann
    Heterologous expression of NaV1.9 chimeras in various cell systems.  
    Pflügers Archiv, European Journal of Physiology 467 2423-2435 PMID: 25916202

    Tian, Y., F. Ullrich, R. Xu, S.H. Heinemann, S. Hou, T. Hoshi
    Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.
    Journal of General Physiology 145 331-343 PMID: 25825171

    Friebel, K., R. Schönherr, R.W. Kinne, E. Kunisch
    Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients.
    Journal of Cellular Physiology 230 1677-1688 PMID: 25545021

    Goradia, N., C. Wiedemann, C. Herbst, M. Görlach, S.H. Heinemann, O. Ohlenschläger, R. Ramachandran
    An approach to NMR assignment of intrinsically disordered proteins.
    ChemPhysChem 16 739-746 PMID: 25639453

    Mede, R., V.P. Lorett-Velásquez, M. Klein, H. Görls, M. Schmitt, G. Gessner, S.H. Heinemann, J. Popp, M. Westerhausen
    Carbon monoxide release properties and molecular structures of thiophenolatomanganese(I) carbonyl complexes of the type [(OC)4Mn(µ-S-Aryl)]2 (Mn-based CORMs).
    Dalton Transactions 44 3020-3033 PMID: 25569035

  • 2014

    Heimer, P., A.A. Tietze, M. Böhm, R. Giernoth, A. Kuchenbuch, A. Stark, E. Leipold, S.H. Heinemann, C. Kandt, D. Imhof
    Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides.
    ChemBioChem 15 2754-2765 PMID:25376613

    Zhu, Q., S.H. Heinemann, R. Schönherr, G.K.E. Scriba
    Capillary electrophoresis separation of peptide diastereomers that contain methionine sulfoxide by dual cyclodextrin-crown ether systems.
    Journal of Separation Science 37 3548-3554 PMID:25216019

    Zhu, Q., X. Huo, S.H. Heinemann, R. Schönherr, R.G. El-Mergawy, G.K.E. Scriba

    Experimental design-guided development of a stereospecific capillary electrophoresis assay for methionine sulfoxide reductase enzymes using a diastereomeric pentapeptide substrate.
    Journal of Chromatrography A 1359 224-229 PMID:25064531

    Mancini, M., M.V. Soldovieri, G. Gessner, B. Wissuwa, V. Barrese, F. Boscia, A. Secondo, F. Miceli, C. Franco, P. Ambrosino, L.M.T. Canzoniero, M. Bauer, T. Hoshi, S.H. Heinemann, M. Taglialatela
    Critical role of large conductance voltage- and calcium-activated potassium channels in leptin-induced neuroprotection of N-methyl-D-aspartate-exposed cortical neurons.
    Pharmacological Research 87 80-86 PMID:24973659

    Schirmeyer, J., K. Szafranski, E. Leipold, C. Mawrin, M. Platzner, S.H. Heinemann

    Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.
    Channels 8 210-215 PMID:2463188

    Ojha, N.K., E. Nematian-Ardestani, S. Neugebauer, B. Borowski, A. El-Hussein, T. Hoshi, E. Leipold, S.H. Heinemann
    Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.
    BBA Biomembranes 1838 1412-1419 PMID:24513256

    Heinemann, S.H., T. Hoshi, M. Westerhausen, A. Schiller
    Carbon monoxide - physiology, detection and controlled release.
    Chemical Communications 50 3644-3660 PMID: 24556640

    Zhu, Q., R.G. El-Mergawy, S.H. Heinemann, R. Schönherr, P. Jac, G.K.E. Scriba
    Stereospecific electrophoretically mediated microanalysis assay for methionine sulfoxide reductase enzymes.
    Analytical and Bioanalytical Chemistry 406 1723-1729 PMID:24424966

    Ohlenschläger, O., A. Schiller, F. Jahns, S.H. Heinemann
    Bunte Aspekte: Häm und seine Abbauprodukte.
    Nachrichten aus der Chemie 62 119-124

    Glaser, R.W., R. Schönherr, S.H. Heinemann
    Fixed charges in the gel matrix of sensor chips and dissociation in diffusion gradients influence the detection of fast protein-protein interactions.
    BioSystems 116 27-35 PMID:24342363

    Sahoo, N., T. Hoshi, S.H. Heinemann
    Oxidative modulation of voltage-gated potassium channels.
    Antioxid Redox Signal 21 933-952 PMID:24040918

  • 2013

    Hoshi, T., R. Xu, S. Hou, S.H. Heinemann, Y. Tian
    A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.
    The Journal of General Physiology 142 507-522 PMID: 24127525

    Sahoo, N., N. Goradia, O. Ohlenschläger, R. Schönherr, M. Friedrich, W. Plass, R. Kappl, T. Hoshi, S.H. Heinemann
    Heme impairs the ball-and-chain inactivation of potassium channels.
    Proceedings of the National Academy of Sciences USA Plus 110 E4036-4044 PMID: 24082096

    Heinemann, S.H., M. Bauer
    Gesundes Fett im Fisch: Blutdrucksenkende Wirkung von Omega-3-Fettsäuren
    Labor & more 6.13 44-48

    Leipold, E., L. Liebmann, G.C. Korenke, T. Heinrich, S. Gießelmann, J. Baets, M. Ebbinghaus, R.O. Goral, T. Stödberg, J.C. Hennings, M. Bergmann, J. Altmüller, H. Thiele, A. Wetzel, P. Nürnberg, V. Timmerman, P. de Jonghe, R. Blum, H.-G. Schaible, J. Weis, S.H. Heinemann, C.A. Hübner, I. Kurth
    A de novo gain-of-function mutation in SCN11A causes loss of pain perception.
    Nature Genetics 45 1399-1404 PMID: 24036948

    Hoshi, T., B. Wissuwa, T. Tian, N. Tajima, R. Xu, M. Bauer, S.H. Heinemann, S. Hou
    Differential impacts of omega-3 fatty acids and their derivatives on blood pressure.
    Proceedings of the National Academy of Sciences USA 110 E2260 PMID: 23940844

    Zhu, Q., R.G. Abdelaleem, P. Jac, S.H. Heinemann, R. Schönherr, G.K.E. Scriba
    Stereospecific micellar electrokinetic chromatography assay of methionine sulfoxide reductase enzymes employing a multiple-layer coated capillary.
    Electrophoresis 34 2712-2717 PMID: 23775584

    Kühl, T., A. Wißbrock, N. Goradia, N. Sahoo, K. Galler, U. Neugebauer, J. Popp, S.H. Heinemann, O. Ohlenschläger, D. Imhof
    Analysis of Fe(III) heme binding to cysteine-containing heme-regulatory motifs in proteins.
    ACS Chemical Biology 8 1785-1793 PMID: 23730736

    Jazzazi, T.M.A., H. Görls, G. Gessner, S.H. Heinemann, M. Westerhausen
    Photosensitive iron(II)-based CO releasing molecules (CORMs) with vicinal amino and diphenylphosphino substituted chelating ligands.
    Journal of Organometallic Chemistry 733 63-70

    Hoshi, T., B. Wissuwa, Y. Tian, N. Tajima, R. Xu, M. Bauer, S.H. Heinemann, S. Hou
    Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels.
    Proceedings of the National Academy of Sciences USA 110 4816-4821

    Hoshi, T., Y. Tian, R. Xu, S.H. Heinemann, S. Hou
    Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA.
    Proceedings of the National Academy of Sciences USA 110 4822-4827

  • 2012

    Pohle, W.
    The Potential Binding Potency of Biological Molecules
    in:  "Advances in Chemistry Research", Vol. 11 (J. C. Taylor, Ed.) Nova Science Publishers, Hauppauge, New York (2012) pp. 1-74.

    Stengel, R., E. Rivera-Milla, N. Sahoo, C. Ebert, F. Bolling, S.H. Heinemann, R. Schönherr, C. Englert
    Kcnh1 voltage-gated potassium channels are essential for zebrafish early embryonic development.
    Journal of Biological Chemistry 287 35565-35575 PMID: 22927438

    Sponholz, C., K. Huse, M. Kramer, E.J. Giamarellos-Bourboulis, R.A. Claus, A. Kern, C. Engel, E. Kuhnt, M. Kiehntopf, C. Routsi, V. Mylona, I. Tsangaris, S.H. Heinemann, K. Reinhart, M. Platzer, M. Bauer
    Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.
    Shock 38 459-465

    Heinemann, S.H.
    Visualizing individual sodium channels on the move.
    Chemistry and Biology 19 790-791 PMID: 22840766

    Quast, S.A., A. Berger, N. Buttstädt, K. Friebel, R. Schönherr, J. Eberle
    General sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC.
    PLoS One. 2012;7(6):e39290. Epub 2012 Jun 18.

    Marques-Carvalho, M.J., N. Sahoo, F.W. Muskett, R.S. Vieira-Pires, G. Gabant, M. Cadene, R. Schönherr, J.H. Morais-Cabral
    Structural, biochemical and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel.
    Journal of Molecular Biology 423 34-46

    Markgraf, R., E. Leipold, J. Schirmeyer, M. Paolini-Bertrand, O. Hartley, S.H. Heinemann
    Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC.
    British Journal of Pharmacology 167 576-586 PMID: 22537004

    Leipold, E., A. Borges, S.H. Heinemann
    Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes.
    Journal of General Physiology 139 305-319 PMID: 22331907

    Tietze, A.A., D. Tietze, O. Ohlenschläger, E. Leipold, F. Ullrich, A. Mischo, M. Görlach, S.H. Heinemann, D. Imhof
    Structurally diverse µ-conotoxin PIIIA isomers block sodium channel NaV1.4.
    Angewandte Chemie International Edition 51 4058-4061 PMID: 22407516

    Sahoo, N., R. Schönherr, T. Hoshi, S.H. Heinemann
    Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels.
    Biochimica et Biophysica Acta - Biomembranes 1818 1187-1195 PMID: 22310694

    Gessner, G., Y.-M. Cui, Y. Otani, T. Ohwada, M. Soom, T. Hoshi, S.H. Heinemann
    Molecular mechanism of pharmacological activation of BK channels.
    Proceedings of the National Academy of Sciences, USA 109 3552-3557 PMID: 22331907

    Bauer, M., O.W. Witte , S.H. Heinemann
    Carbon monoxide and outcome of stroke-A dream CORM true?
    Critical Care Medicine 40 687-688 PMID: 22249054

    Velasquez, V.P.L., T.M.A. Jazzazi, A. Malassa, H. Görls, G. Gessner, S.H. Heinemann, M. Westerhausen
    Derivatives of photosensitive CORM-S1: CO complexes of iron and ruthenium with the (OC)2M(S-C-C-NH2)2 fragment.
    European Journal of Inorganic Chemistry 2012 1072-1078

    Favreau, Ph., E. Benoit, H.G. Hocking, L. Carlier, D. D'hoedt, E. Leipold, R. Markgraf, S. Schlumberger, M.A. Córdova, H. Gaertner, M. Paolini-Bertrand, O. Hartley, J. Tytgat, S.H. Heinemann, D. Bertrand, R. Boelens, R. Stöcklin, J. Morgó
    A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV 1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.
    British Journal of Pharmacology 166 1654-1668 PMID: 22229737

  • 2011

    Kühl, T., N. Sahoo, M. Nikolajski, B. Schlott, S.H. Heinemann, D. Imhof
    Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach.
    ChemBioChem 12 2846-2855

    Handbook of Biophotonics, Vol. 2: Photonics for Health Care. Edts: J. Popp, V.V. Tuchin, A. Chiou, S.H. Heinemann, WILEY-VCH Verlag & Co. KGaA, Weinheim

    Handbook of Biophotonics, Vol. 1: Basics and Techniques. Edts: J. Popp, V.V. Tuchin, A. Chiou, S.H. Heinemann, WILEY-VCH Verlag & Co. KGaA, Weinheim

    Leipold, E., R. Markgraf, A. Miloslavina, M. Kijas, J. Schirmeyer, D. Imhof, S.H. Heinemann
    Molecular determinants of the subtype specificity of µ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.
    Neuropharmacology 61 105-111

    Seidel, K.N., C. Derst, M. Salzmann, M. Höltje, J. Priller, R. Markgraf, S.H. Heinemann, H. Heilmann, S.N. Skatchkov, M.J. Eaton, R.W. Veh, H. Prüss
    Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKb1 and BKb4 in rodent astrocytes.
    Glia 59 893-902

    Carella, M., J. Becher, O. Ohlenschläger, R. Ramachandran, K.H. Gührs, G. Wellenreuther, W. Meyer-Klaucke, S.H. Heinemann, M. Görlach
    Structure-function relationship in an archaebacterial methionine sulfoxide reductase B.
    Molecular Microbiology 79 342-358

    Neugebauer, U., S.H. Heinemann, M. Schmitt, J. Popp
    Combination of patch clamp and Raman spectroscopy for single-cell analysis.
    Analytical Chemistry 83 344-350

    Kretschmer, R., G. Gessner, H. Görls, S.H. Heinemann, M. Westerhausen
    Dicarbonyl-bis(cysteamine)iron(II): a light induced carbon monoxide releasing molecule based on iron (CORM-S1).
    Journal of Inorganic Biochemistry 105 6-9

    Hou, S., R. Xu, J.F. Clark, W.L. Wurster, S.H. Heinemann, T. Hoshi
    Bilirubin oxidation end products (BOXes) directly alter K+ channels important in regulation of vascular tone.
    Journal of Cerebral Blood Flow & Metabolism 31 102-112

  • 2010

    Baumgart, M., C. Feller, G. Natura, T. Dahse, H.G. Schaible, I. Dahse
    Blockade of TTX-resistant and TTX-sensitive Na+ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000.
    Brain Research 1358 54-63

    Sahoo, N., J. Tröger, S.H. Heinemann, R. Schönherr
    Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B.
    FEBS Letters 584 3896-3900

    Schmidt, J., K. Friebel, R. Schönherr, M.G. Coppolino, A.K. BosserhoffS
    Migration-associated secretion of melanoma inhibitory activity (MIA) at the cell rear is supported by KCa3.1 potassium channels.
    Cell Research 20 1224-1238

    Gauger, D.R., V.V. Andrushchenko, P. Bour, W. Pohle
    A spectroscopic method to estimate the binding potency of amphiphile assemblies.
    Analytical and Bioanalytical Chemistry 398 1109-1123

    Kolbe, K., R. Schönherr, G. Gessner, N. Sahoo, T. Hoshi, S.H. Heinemann
    Cysteine 723 in the C-linker segment confers oxidation inhibition of hERG1 potassium channels.
    The Journal of Physiology 588 2999-3009

    König, C., O. Gavrilova-Ruch, G. Segond von Bachet, R. Bauer, M. Grün, E. Hirsch, I. Rubio, S. Schulz, S.H. Heinemann, H.G. Schaible, R. Wetzker
    Modulation of µ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ.
    Neuroscience 169 449-454

    Binger, K.J., M.D.W. Griffin, S.H. Heinemann, G.J. Howlett
    Methionine oxidized amyloid fibrils are poor substrates for human methionine sulfoxide reductases A & B2.
    Biochemistry 49 2981-2983

    Eberle, J., B. Spangler, J. Becker, S.H. Heinemann, C.A. Klein, M. Kunz, S. Kuphal, P. Langer, C. Mauch, S. Meierjohann, A. Paschen, D. Schadendorf, M. Schartl, B. Schittek, R. Schönherr, T. Tueting, P. Zigrino, A.K. Bosserhoff
    Multicentre study on standardisation of melanoma cell culture - an initiative of the German Melanoma Research Network.
    Pigment Cell & Melanoma Research 23 296-298

    Gessner, G., R. Macianskiene, J.G. Starkus, R. Schönherr, S.H. Heinemann
    The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.
    European Journal of Pharmacology 632 52-59

    Hou, S., L.E. Vigeland, G. Zhang, R. Xu, M. Li, S.H. Heinemann, T. Hoshi
    Zn2+ activates large-conductane Ca2+ -activated K+ channel via an intracellular domain.
    Journal of Biological Chemistry 285 6434-6442

    Zhang, J.T., S. Petersen, M. Thunga, E. Leipold, R. Weidisch, X. Liu, A. Fahr, K.D. Jandt
    Micro-structured smart hydrogels with enhanced protein loading and release efficiency
    Acta Biomaterialia 6 1297-1306

    Schirmeyer, J., K. Szafranski, E. Leipold, C. Mawrin, M. Platzer, S.H. Heinemann
    A subtle alternative splicing event of the NaV1.8 voltage-gated sodium channel is conserved in human, rat, and mouse.
    Journal of Molecular Neuroscience 41 310-314

  • 2009

    Pohle, W., Gauger, D.R.
    Solid-state primary aliphatic amines are actually ammonium amides as revealed by infrared spectroscopy.
    Journal of Molecular Structure 924-926 144-147

    Wicher, D., R. Schäfer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, B.S. Hansson

    dOr83b--receptor or ion channel?
    Ann N Y Acad Sci. 1170 164-167

    Discher, S., A. Burse, K. Tolzin-Banasch, S.H. Heinemann, J.M. Pasteels, W. Boland

    A versatile transport network for sequestering and excreting plant glycosides in leaf beetles provides an evolutionary flexible defense strategy.
    Chembiochem 10 2223-2229

    Hou, S., F.T. Horrigan, R. Xu, S.H. Heinemann, T. Hoshi
    Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels.
    Channels 3 249-258

    Wassef, R., S.H. Heinemann, T. Hoshi
    Treating oxidative neural injury: methionine sulfoxide reductase therapy for Parkinson disease. In S.C. Veasey (ed.) Oxidative Neural Injury.
    Humana Press. Contemporary Clinical Neuroscience, 193-206

    Hou, S., S.H. Heinemann, T. Hoshi
    Modulation of BKCa channel gating by endogenous signaling molecules.
    Physiology (Bethesda) 24 26-35

    Miloslavina, A.A., E. Leipold, M. Kijas, A. Stark, S.H. Heinemann, D. Imhof

    A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides.
    Journal of Peptide Science 14 72-77

  • 2008

    Haenold, R., R. Wassef, N. Brot, S. Neugebauer, E. Leipold, S.H. Heinemann, T. Hoshi
    Protection of vascular smooth muscle cells by methionine sulfoxide reductase A Role of intracellular localization and substrate availability.
    Free Radical Research 42 978-988

    Decher, N., T. Gonzales, A.K. Streit, F.B. Sachse, V. Renigunta, M. Soom, S.H. Heinemann, J. Daut, M.C. Sanguinetti
    Structural determinants of Kvβ1.3 induced channel inactivation: a hairpin modulated by PIP2.
    The EMBO Journal 27 3164-3174

    Soom M, G. Gessner, H. Heuer, T. Hoshi, S.H. Heinemann
    A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function
    Channels 2 278-282

    Wicher, D., R. Schäfer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, B.S. Hansson
    Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.
    Nature 4521007-1011

    Hou, S., R. Xu, S.H. Heinemann, T. Hoshi
    Reciprocal regulation of the Ca2+ and H+ sensitivity in the Slo1 BK channel conferred by the RCK1 domain.
    Nature Structural and Molecular Biology  15 403-410

    Kassmann, M., A. Hansel, E. Leipold, J. Birkenbeil, S.Q. Lu, T. Hoshi, S.H. Heinemann
    Oxidation of multiple methionine residues impairs rapid sodium channel inactivation.
    Pflügers Archiv 456 1085-1095

    Hou, S., R. Xu, S.H. Heinemann, T. Hoshi
    The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels.
    Proceedings of the National Academy of Sciences, USA 105 4039-4043